Methods and compositions for treating 5alpha-reductase type...

Details Methods and compositions for treating 5alpha-reductase type... Methods and compositions for treating 5alpha-reductase type...

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 9/10 (2006.01) A61K 31/7088 (2006.01) A61K 31/713 (2006.01) A61K 47/48 (2006.01) A61P 5/28 (2006.01) A61P 17/00 (2006.01)

Patent

CA 2543135

The invention relates generally to the use of anti-sense oligonucleotides, small interfereing RNA, and ribozymes to modulate expression of the human steroid 5.alpha.-~reductase gene and thereby modulate levels of dihydrotestosterone (DHT). Elevated levels of DHT are associated with various disorders including, but not limited to, skin diseases, hair loss, hirsuitism, and benign prostatic hyperplasia. The invention specifically relates to formulations of these anti-sense oligonucleotides, small interfering RNA, and ribozymes for administration to treat and prevent disorders.

La présente invention concerne l'utilisation d'oligonucléotides anti-sens, de petits ARN interférants et de ribozymes pour moduler l'expression du gène humain de la 5alpha stéroïde réductase et pour moduler les niveaux de dihydrotestostérone (DHT). Des niveaux élevés de DHT sont associés à divers troubles, parmi lesquels, entre autres, des maladies cutanées, la perte des cheveux, l'hirsutisme, et l'hyperplasie prostatique bénigne. Plus particulièrement, cette invention concerne des formulations de ces oligonucléotides anti-sens, de ces petits ARN interférants, et de ces ribozymes destinées à être administrées afin de traiter et de prévenir des troubles.

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