Methods and compositions for treating and diagnosing...

Details Methods and compositions for treating and diagnosing... Methods and compositions for treating and diagnosing...

G - Physics

01

N

G01N 33/68 (2006.01) A61K 48/00 (2006.01) G01N 33/74 (2006.01)

Patent

CA 2517981

Expression of beta-TRP is enriched in islet cells. Introduction of expression cassettes encoding beta-TRP into diabetic islet cells improved glucose- stimulated insulin production. Therefore, the invention provides methods of identifying beta-TRP modulators for treating diabetic individuals and introducing beta-TRP into islet cells.

Selon la présente invention, l'expression de béta-TRP est augmentée dans des cellules d'îlot. L'introduction de cassettes d'expression codant béta-TRP dans des cellules d'îlot d'une personne diabétique permet d'améliorer la production d'insuline stimulée par glucose. La présente invention concerne des procédés pour identifier des modulateurs de béta-TRP, afin de traiter des personnes diabétiques et d'introduire béta-TRP dans des cellules d'îlot.

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