C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/445 (2006.01) A61K 39/015 (2006.01) A61P 33/06 (2006.01) A61P 37/04 (2006.01) G01N 33/53 (2006.01) C12N 15/30 (2006.01) G01N 33/569 (2006.01)
Patent
CA 2606624
Vaccines, in particular, antigens capable of eliciting antibodies capable of preventing invasion of Plasmodium parasite into erythrocytes, and use of said vaccines for the treatment and/or prevention of malaria. In one embodiment, the antigen is an immunogenic molecule comprising a contiguous amino acid sequence of an erythrocyte binding antigen (EBA) protein of a strain of Plasmodium falciparum, wherein when administered to a subject the molecule is capable of inducing an invasion- inhibitory immune response to the strain. Also disclosed is a method of screening for the presence of a Plasmodium falciparum invasion-inhibitory antibody directed against an erythrocyte binding antigen (EBA) of a strain of Plasmodium falciparum in a subject.
Beeson James
Cowman Alan
Lopaticki Sash
Maier Alexander Gerd
Persson Kristina E.m.
Ridout & Maybee Llp
The Walter And Eliza Hall Institute Of Medical Research
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