A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/704 (2006.01) A61K 31/00 (2006.01) A61K 31/197 (2006.01) A61K 31/69 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2504933
The present invention relates to therapeutic compositions for treating cancer or preventing the growth of cancer cells, e.g., tumor growth, in a subject. The present invention also relates to methods for treating cancer, e.g., inhibiting tumor growth, in a subject who has become resistant to treatment, by administering to a subject an effective amount of a proteasome inhibitor and an effective amount of a therapeutic agent, e.g., a chemotherapeutic agent. The present invention further relates to methods for purging bone marrow, i.e., removing cancer cells from bone marrow, by exposing the bone marrow cells to a proteasome inhibitor and a therapeutic agent, e.g., a chemotherapeutic agent.
L'invention se rapporte à des compositions thérapeutiques de traitement du cancer ou de prévention de la croissance de cellules cancéreuses, p. ex. la croissance tumorale, chez un individu. L'invention se rapporte également à des méthodes de traitement du cancer, p. ex l'inhibition de la croissance tumorale, chez un individu qui est devenu résistant au traitement, par administration à un individu d'une dose efficace d'un inhibiteur de la protéasome et d'une dose efficace d'un agent thérapeutique, p. ex. un agent chimiothérapeutique. L'invention se rapporte par ailleurs à des méthodes de purge de la moelle osseuse, c.-à-d. à extraire les cellules cancéreuses de la moelle osseuse, par exposition des cellules de la moelle osseuse à un inhibiteur de la protéasome et à un agent thérapeutique, p.ex. un agent chimiothérapeutique.
Anderson Kenneth C.
Hideshima Teru
Mitsiades Constantine S.
Mitsiades Nicholas
Dana-Farber Cancer Institute Inc.
Riches Mckenzie & Herbert Llp
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