Methods and compositions for treating conditions of the eye

A - Human Necessities – 61 – K

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A61K 41/00 (2006.01) A61K 38/10 (2006.01) A61P 27/02 (2006.01) A61P 27/06 (2006.01)

Patent

CA 2714081

Provided are methods and compositions for the photodynamic therapy (PDT) of ocular conditions characterized by the presence of unwanted choroidal neovasculature, for example, neovascular age-related macular degeneration. The selectivity and sensitivity of the PDT method can be enhanced by combining the PDT with an anti-angiogenesis factor, for example, angiostatin or endostatin, or with an apoptosis-modulating factor. Furthermore, the selectivity and sensitivity of the PDT may be further enhanced by coupling a targeting moiety to the photosensitizer so as to target the photosensitizer to choroidal neovasculature.

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