A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 41/00 (2006.01) A61K 38/10 (2006.01) A61P 27/02 (2006.01) A61P 27/06 (2006.01)
Patent
CA 2714081
Provided are methods and compositions for the photodynamic therapy (PDT) of ocular conditions characterized by the presence of unwanted choroidal neovasculature, for example, neovascular age-related macular degeneration. The selectivity and sensitivity of the PDT method can be enhanced by combining the PDT with an anti-angiogenesis factor, for example, angiostatin or endostatin, or with an apoptosis-modulating factor. Furthermore, the selectivity and sensitivity of the PDT may be further enhanced by coupling a targeting moiety to the photosensitizer so as to target the photosensitizer to choroidal neovasculature.
Gragoudas Evangelos S.
Miller Joan W.
Renno Reem Z.
Massachusetts Eye And Ear Infirmary
Mbm Intellectual Property Law Llp
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