Methods and compositions for treating diabetes, metabolic...

A - Human Necessities – 61 – K

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A61K 31/496 (2006.01) A61P 3/00 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 9/10 (2006.01) A61P 13/12 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2594433

Pharmaceuticals compositions comprising the 2S, 4R, ketoconazole enantiomer or its pharaceutically acceptable salts, hydrates, and solvates, that are substantially freee of the 2R, 4S ketoconazole enantiomer are useful to reduce cortisol synthese and for the treatment of type 2 diabetes, hyperglycemia, obesity, insulin resistance, dyslipidemia, hyperlipidemia, hypertension, Metabolic Syndrome, and other diseases and conditions, including but not limited to Cushing's Syndrome, depression, and glaucoma.

La présente invention a trait à des compositions pharmaceutiques comprenant l'énantiomère de cétokonazole 2S, 4R ou ses sels, hydrates, et solvates pharmaceutiquement acceptables, qui sont essentiellement exempts de l'énantiomère de cétokonazole 2R, 4S utiles pour la réduction de la synthèse de cortisol et pour le traitement du diabète de type II, de l'hyperglycémie, de l'obésité, de la résistance à l'insuline, de la dyslipidémie, de l'hyperlipidémie, de l'hypertension, du syndrome métabolique et d'autres maladies et conditions mais non limitées au syndrome de Cushing, de la dépression et du glaucome.

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