A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/18 (2006.01) A01K 67/027 (2006.01) A61P 9/10 (2006.01) A61P 13/12 (2006.01) A61P 17/02 (2006.01)
Patent
CA 2530866
The present invention provides a method for altering the level of an extracellular matrix (ECM) protein produced by a cell, the method including modulating expression or activity of a cell division auto antigen (CDA). The Applicants have surprisingly found that a CDA is involved in a pathway that controls the level of ECM protein produced by mammalian cells. The invention has relevance to a number of ECM-related disorders such as renal fibrosis and atherosclerosis.
L'invention concerne une méthode servant à modifier le niveau d'une protéine de matrice extracellulaire (ECM) produite par une cellule, ce qui consiste à moduler l'expression ou l'activité d'un auto-antigène de division cellulaire (CDA). On a découvert que CDA joue un rôle dans le trajet contrôlant le niveau de la protéine de matrice extracellulaire (ECM) produite par des cellules mammifères. L'invention peut s'appliquer à certaines maladies associées à ECM, telles que la fibrose rénale ou l'athérosclérose.
Cao Zemin
Chai Zhonglin
Cooper Mark Emmanuel
Baker Medical Research Institute
Dia-B Tech Limited
Sim & Mcburney
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