Methods and compositions for treating dry eye

Details Methods and compositions for treating dry eye Methods and compositions for treating dry eye

A - Human Necessities

61

K

A61K 38/39 (2006.01) A61K 31/736 (2006.01) A61P 27/02 (2006.01) A61P 27/04 (2006.01)

Patent

CA 2703814

The present invention is directed to ophthalmic compositions containing protease-inhibiting peptide substrates. In a preferred embodiment, the protease-inhibiting peptide substrate is gelatin. The compositions may also contain a galactomannan. In a particularly preferred embodiment, the compositions contain gelatin, a galactomannan and a borate salt. The present invention also describes methods of use of these compositions to inhibit protease MMP-9, and methods of topical administration of the compositions to the eye, particularly for the treatment of dry eye.

L'invention concerne des compositions ophtalmiques contenant des substrats peptidiques inhibant une protéase. Dans un mode de réalisation préféré, le substrat peptidique inhibant une protéase est de la gélatine. Les compositions peuvent également contenir un galactomannane. Dans un mode de réalisation particulièrement préféré, les compositions contiennent de la gélatine, un galactomannane et un sel de borate. La présente invention décrit également des procédés d'utilisation de ces compositions pour inhiber la protéase MMP-9, et des procédés d'administration topique des compositions à l' il, en particulier pour le traitement d'un il sec.

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