A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/575 (2006.01) A61K 31/16 (2006.01) A61K 31/192 (2006.01) A61P 3/06 (2006.01) A61P 9/10 (2006.01)
Patent
CA 2679608
The invention provides compounds and pharmaceutical compositions that can be used to treat or prevent atherosclerosis, stroke, and other ischemic vascular diseases, dyslipidemia and hypercholesterolemia and prevent complications of these conditions. Agents in accordance with the invention include; tauroursodeoxycholic acid (TUDCA), and analogs and derivatives thereof; 4-phenyl butyric acid (PBA), and analogs and derivatives thereof; and trimethyl N-oxide (TMAO), and analogs and derivatives thereof.
L'invention concerne des composés et des compositions pharmaceutiques qui peuvent servir à traiter ou prévenir l'athérosclérose, les accidents vasculaires cérébraux et d'autres maladies vasculaires ischémiques, les dyslipidémies et l'hypercholestérolémie, et à prévenir les complications associées auxdits états pathologiques. Les agents selon l'invention contiennent : de l'acide tauroursodésoxycholique (TUDCA) et ses analogues et dérivés; de l'acide 4-phényle butyrique (PBA) et ses analogues et dérivés; et du triméthyle N-oxyde (TMAO) et et ses analogues et dérivés.
Hotamisligil Gokhan S.
Ozcan Umut
Gowling Lafleur Henderson Llp
President And Fellows Of Harvard College
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