Methods and compositions for treating ige-related disease...

A - Human Necessities – 61 – K

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A61K 39/395 (2006.01) A61K 38/17 (2006.01) A61P 37/08 (2006.01) C07K 16/24 (2006.01) G01N 33/564 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2419274

Disclosed are methods and compositions for treating IgE-related diseases using NNT-1 inhibitors. In one embodiment, the present invention relates to a method of treating IgE-related diseases using a selective binding agent to NNT-1. In another embodiment, the present invention relates to a method of treating IgE- related diseases using an NNT-1 expression modulator. Methods of modulating IgE levels, and of diagnosing, preventing and/or treating certain types of allergic diseases using NNT-1 inhibitors are also disclosed.

L'invention concerne de nouvelles méthodes et compositions permettant de traiter des maladies liées à l'IgE au moyen d'inhibiteurs du NNT-1. Dans un mode de réalisation, la présente invention concerne une méthode de traitement de maladies liées à l'IgE, faisant appel à un agent se fixant sélectivement sur le NNT-1. Dans un autre mode de réalisation, la présente invention concerne une méthode de traitement de maladies liées à l'IgE, faisant appel à un agent modulant l'expression du NNT-1. L'invention concerne également des méthodes permettant de moduler les taux d'IgE et de diagnostiquer, prévenir et/ou traiter certains types de maladies allergiques au moyen d'inhibiteurs de NNT-1.

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