Methods and compositions for treating immune disorders

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/11 (2006.01) A61K 31/7088 (2006.01) A61K 31/7125 (2006.01) A61P 37/04 (2006.01) C07H 21/00 (2006.01)

Patent

CA 2625488

The present invention provides oligonucleotides, compositions comprising them and methods that use the oligonucleotides and compositions for stimulating cells expressing the TLR7 and/or TLR8 receptor. The oligonucleotides comprise for stimulating TLR7 comprise uracil-rich regions. The oligonucleotides for stimulating TLR8 comprise guanine-rich regions. The present methods and compositions are useful, inter alia, for treating or preventing conditions such as infectious disease and cancer.

L'invention concerne des oligonucléotides, des compositions comprenant ces oligonucléotides et des méthodes d'utilisation des oligonucléotides et des compositions afin de stimuler des cellules exprimant le récepteur TLR7 et/ou TLR8. Les oligonucléotides permettant de stimuler TLR7 comprennent des régions riches en uracile. Les oligonucléotides permettant de stimuler TLR8 comprennent des régions riches en guanine. Les méthodes et les compositions de l'invention sont utilisées, notamment, pour traiter ou prévenir des états pathologiques, tels que les maladies infectieuses et le cancer.

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