A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/10 (2006.01) A61K 31/195 (2006.01) A61K 45/06 (2006.01) A61P 29/00 (2006.01)
Patent
CA 2732764
Methods and compositions are provided for the treatment of inflammation and disorders, diseases, and adverse conditions, i.e., pathologies, caused by or otherwise associated with inflammatory processes. A metal ion sequestering agent that directly or indirectly exerts an anti-inflammatory effect is administered to a subject in combination with a sequestration inactivating moiety that facilitates transport of the metal ion sequestering agent through biological membranes. The sequestration inactivating moiety also inactivates the metal ion sequestering agent until association between the two components is cleaved in vivo to release the active sequestering agent. Compositions containing a metal ion sequestering agent and a sequestration inactivating moiety are also provided; the compositions optionally contain an added anti-inflammatory agent.
L'invention concerne des procédés et des compositions destinés au traitement d'une inflammation et de troubles, de maladies, et d'états défavorables, c'est-à-dire des pathologies provoquées par des processus inflammatoires ou sinon associées à ceux-ci. Un agent de séquestration d'ion métallique qui exerce directement ou indirectement un effet anti-inflammatoire est administré à un sujet en combinaison avec un fragment d'inactivation de séquestration qui facilite le transport de l'agent de séquestration d'ion métallique à travers des membranes biologiques. Le fragment d'inactivation de séquestration inactive également l'agent de séquestration d'ion métallique jusqu'à ce que l'association entre les deux composants soit clivée in vivo pour libérer l'agent de séquestration actif. Des compositions contenant un agent de séquestration d'ion métallique et un fragment d'inactivation de séquestration sont également fournies ; les compositions contiennent facultativement un agent anti-inflammatoire ajouté.
Bhushan Rajiv
Duffield Christopher
Gin Jerry B.
Goswamy Amit
Fetherstonhaugh & Co.
Livionex Inc.
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