Methods and compositions for treating, inhibiting and...

A - Human Necessities – 61 – K

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A61K 31/7088 (2006.01) A61K 31/713 (2006.01)

Patent

CA 2594349

Described herein are methods and compositions for inhibiting, treating and reversing intervertebral disc disorders using transcription factor inhibitors. In certain embodiments, the transcription factor inhibitor targets the transcription factor NF-.kappa.B. Also described are methods and compositions where intervertebral disc disorder is reversed using a decoy oligodeoxy- nucleotide that blocks NF-.kappa.B.

L'invention concerne des méthodes et des compositions destinées à inhiber, traiter et inverser des discopathies intervertébrales au moyen d'inhibiteurs de facteurs de transcription. Dans certains modes de réalisation, l'inhibiteur de facteur de transcription est ciblé sur le facteur de transcription NF-?B. L'invention concerne également des méthodes et des compositions permettant d'inverser une discopathie intervertébrale au moyen d'un oligodésoxynucléotide leurre bloquant NF-?B.

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