Methods and compositions for treating intervertebral disc...

A - Human Necessities – 61 – L

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A61L 27/36 (2006.01) A61K 35/32 (2006.01) A61L 27/38 (2006.01) A61L 27/54 (2006.01) A61P 19/00 (2006.01) A61F 2/44 (2006.01)

Patent

CA 2400826

A fluid matrix comprising cross-linked remodelable collagen from a donor vertebrate animal is useful for regener-ating hydrodynamic function in damaged intervertebral discs in vivo. The matrix may be injectable and may comprise cells and a plurality of purified cell growth factors. The matrix promotes cell growth and elaboration of proteoglycans to facilitate regeneration of native tissues. The collagen in the matrix may be cross-linked using photooxidative catalysis and visible light, and purified cell growth factors are preferably at least partly bone-derived.

La présente invention concerne une matrice fluide comprenant du collagène remodelable réticulé provenant d'un donneur animal vertébré qui convient pour régénérer la fonction hydrodynamique dans des disques intervertébraux in vivo. Cette matrice peut être injectable et peut comprendre des cellules et une pluralité de facteurs de croissance de cellule purifiés. Cette matrice favorise la croissance cellulaire et l'élaboration de protéoglycanes de façon à faciliter la régénération des tissus endogènes. Le collagène présent dans la matrice peut être réticulé par catalyse photo-oxydative et par la lumière visible, et les facteurs de croissance de cellule purifiés sont de préférence au moins en partiellement dérivés d'os.

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