C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 323/60 (2006.01) A61K 31/277 (2006.01) A61K 31/428 (2006.01) A61P 35/02 (2006.01) C07D 277/74 (2006.01)
Patent
CA 2367832
Compounds of general formula (I), wherein R1 is H or C1 to C3 alkyl; R2 is aryl or -(CH2)n-aryl and n is 1 to 4; R3 is H or CH3; and R4 is substituted or unsubstituted phenyl, pyridyl, thiophene, furan, indole, pyrrole, thiazole or imidazole are described, as well as methods for treating cell proliferative disorders and neoplastic disorders.
La présente invention concerne des composés de formule générale (I): dans laquelle R¿1? est un H ou un groupe alkyle en C1-C3, R¿2? est un groupe aryle ou un groupe -(CH¿2?)¿n?-aryle et n prend la valeur de 1 à 4, R¿3? est un H ou un groupe CH¿3?, et R¿4? est un groupe phényle, pyridyle, thiophène, furane, indole, pyrrole, thiazole ou imidazole substitué ou non substitué. L'invention concerne aussi des procédés de traitement de troubles de prolifération cellulaire et des troubles néoplastiques.
Gazit Aviv
Levitzki Alexander
Roifman Chaim M.
Hsc Research And Development Limited Partnership
Sim & Mcburney
Yissum Research Development Company Of The Hebrew University Of
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