Methods and compositions for treating liquid tumors

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/506 (2006.01) A61K 31/505 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2708262

The application relates to a method of using compositions having anti-alpha- 4 integrin and/or anti- alpha-9 integrin activity to inhibit liquid tumor growth, malignancies thereof and/or development of metastases thereof that involve expression of an alpha-4 integrin and/or alpha-9 integrin. Pharmaceutical compositions and combination therapies (for example, with chemotherapies) for the inhibition of liquid tumor growth, malignancies thereof and/or development of metastases thereof are also provided.

L'invention concerne un procédé d'utilisation de compositions ayant une activité anti-alpha-4-intégrine et/ou anti-alpha-9-intégrine pour inhiber la croissance de tumeur liquide, la malignité de celle-ci et/ou le développement de métastases de celle-ci qui entraînent l'expression d'une alpha-4-intégrine et/ou d'une alpha-9-intégrine. L'invention propose également des compositions pharmaceutiques et des thérapies par combinaison (par exemple avec des chimiothérapies) pour l'inhibition de la croissance de tumeur liquide, de la malignité de celle-ci et/du développement de métastases de celle-ci.

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