A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/09 (2006.01) A61P 1/00 (2006.01) C12N 15/74 (2006.01)
Patent
CA 2689658
The invention relates generally to the field of mucositis. More particularly, the present invention relates to methods and compositions for treating and preventing mucositis. In particular for treating or preventing oral mucositis, especially stomatitis and esophagitis. The invention generally relates to the use of recombinant non-pathogenic and non-invasive microorganisms, in particular recombinant bacterium or yeast expressing a trefoil peptide in particular in combination with one or more factors that target the mucus, tight junctions or extracellular matrix and/or factors typically used in the treatment of mucositis.
L'invention concerne d'une manière générale le domaine de la mucosite. Plus particulièrement, la présente invention porte sur des procédés et des compositions pour traiter et prévenir la mucosite. En particulier, pour traiter ou prévenir la mucosite orale, notamment la stomatite et l'AEsophagite. D'une manière générale, l'invention porte sur l'utilisation de micro-organismes recombinants non pathogènes et non invasifs, en particulier une bactérie ou levure recombinante exprimant un peptide en trèfle, en particulier en combinaison avec un ou plusieurs facteurs qui ciblent le mucus, des jonctions étroites ou la matrice extracellulaire et/ou des facteurs typiquement utilisés dans le traitement de la mucosite.
Rottiers Pieter
Actogenix Nv
Sim & Mcburney
LandOfFree
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