A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01)
Patent
CA 2561714
Disclosed herein are engineered zinc finger proteins which modulate transcription of the gene encoding vascular endothelial growth factor-A (VEGF- A) and other genes encoding products with neurotrophic activities. Also disclosed are methods for the use of these engineered zinc finger proteins in the treatment of neuropathy (including diabetic neuropathy), and other types of neural injury and neurodegeneration.
L'invention concerne des protéines à doigts de zinc recombinées qui modulent la transcription du gène codant pour le facteur de croissance endothéliale A (VEGF-A) et d'autres produits géniques codants présentant des activités neurotrophiques. L'invention concerne également des méthodes d'utilisation de ces protéines à doigts de zinc pour le traitement des neuropathies (y compris de la neuropathie diabétique), et d'autres types de lésions nerveuses et de neurodégénérations.
Martin J. Tyler
Kirby Eades Gale Baker
Sangamo Biosciences Inc.
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