Methods and compositions for treating neuropathies

Details Methods and compositions for treating neuropathies Methods and compositions for treating neuropathies

A - Human Necessities

61

K

A61K 31/05 (2006.01) A61K 31/12 (2006.01) A61K 31/352 (2006.01) A61K 31/353 (2006.01) A61K 45/06 (2006.01) A61K 49/00 (2006.01) A61P 25/02 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2676609

Methods of treating or preventing axonal degradation in neuropathic diseases and neurological disorders in mammals are disclosed. The methods can comprise administering to the mammal an effective amount of an agent that acts at least in part by increasing sirtuinAMPK activity, LKB 1 activity and/or CaMKK.beta. activity in diseased and/or injured neurons. The methods can also comprise administering to the mammal an effective amount of an agent that acts by increasing NAD activity in diseased and/or injured neurons, alone or in combination with agents that act by other mechanisms. Also disclosed are methods of screening agents for treating a neuropathies and recombinant vectors for treating or preventing such neuropathies.

L'invention concerne des méthodes de traitement ou de prévention de la dégradation axonale dans des maladies neuropathiques et des troubles neurologiques chez des mammifères. Les méthodes peuvent consister à administrer au mammifère une quantité efficace d'un agent qui agit au moins partiellement par accroissement de l'activité de la sirtuine AMPK, de l'activité de LKB 1 et/ou de l'activité de CaMKK.beta. dans les neurones malades et/ou abîmés. Les méthodes de l'invention peuvent également consister à administrer au mammifère une quantité efficace d'un agent qui agit par accroissement de l'activité du NAD dans les neurones malades et/ou abîmés, seul ou en combinaison avec des agents agissant par d'autres mécanismes. L'invention concerne également des méthodes de criblage d'agents destinés à traiter des neuropathies, et des vecteurs recombinants destinés à traiter ou à prévenir ces neuropathies.

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