A - Human Necessities – 01 – N
Patent
A - Human Necessities
01
N
A01N 43/04 (2006.01) A61K 31/70 (2006.01) C07H 19/00 (2006.01) C07H 19/22 (2006.01)
Patent
CA 2567848
Methods of treating or preventing axonal degradation in neuropathic diseases in mammals are disclosed. The methods can comprise administering to the mammal an effective amount of an agent that acts by increasing sirtuin activity in diseased and/or injured neurons. The methods can also comprise administering to the mammal an effective amount of an agent that acts by increasing NAD activity in diseased and/or injured neurons. Also disclosed are methods of screening agents for treating a neuropathies and recombinant vectors for treating or preventing neuropathies.
L'invention concerne des méthodes de traitement ou de prévention de la dégradation axonale dans des maladies neuropathiques chez des mammifères. Les méthodes peuvent consister à administrer au mammifère une quantité efficace d'un agent agissant par accroissement de l'activité de la sirtuine dans les neurones malades et/ou abîmés. Les méthodes peuvent également consister à administrer au mammifère une quantité efficace d'un agent agissant par accroissement de l'activité du NAD dans les neurones malades et/ou abîmés. L'invention concerne également des procédés de criblage d'agents permettant de traiter des neuropathies et des vecteurs recombinants permettant de traiter ou de prévenir des neuropathies.
Araki Toshiyuki
Milbrandt Jeffrey
Sasaki Yo
Smart & Biggar
Washington University
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