Methods and compositions for treating obesity

Details Methods and compositions for treating obesity Methods and compositions for treating obesity

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61K 45/06 (2006.01) A61K 49/00 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2572638

The present invention relates to therapeutic compositions for treating or preventing obesity and obesity-related disorders in a subject. The present invention also relates to the use of PGC-1 expression levels to determine the safe dosage range for known or putative respiration uncoupling agents for use as anti-obesity therapeutics. The present invention further relates to methods for identifying new compounds that have respiration uncoupling activity.

Cette invention se rapporte à des compositions thérapeutiques servant à traiter ou à prévenir l~obésité et les troubles liés à l~obésité chez un sujet. L~invention concerne également l~utilisation des niveaux d~expression de PGC-1 pour déterminer la gamme posologique sûre pour l~utilisation d~agents découplants connus ou présumés dans la chaîne respiratoire à des fins thérapeutiques pour lutter contre l~obésité. Cette invention concerne également des procédés d~identification de nouveaux composés qui présentent une activité découplante respiratoire.

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