Methods and compositions for treating ophthalmic conditions...

A - Human Necessities – 61 – K

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A61K 31/167 (2006.01) A61K 45/00 (2006.01) A61K 45/06 (2006.01) A61P 27/02 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01)

Patent

CA 2655036

Compounds that cause reversible night blindness may be used to treat ophthalmic conditions associated with the overproduction of waste products that accumulate during the course of the visual cycle. Provided are methods and compositions using such compounds and their derivatives to treat, for example, the macular degenerations and dystrophies or to alleviate symptoms associated with such ophthalmic conditions. Such compounds and their derivatives may be used as single agent therapy or in combination with other agents or therapies.

Cette invention a pour objet des composés qui provoquent une cécité nocturne réversible et qui peuvent être utilisés pour traiter des conditions ophtalmiques associées à la surproduction de produits de déchets qui s'accumulent pendant l'évolution du cycle visuel. Des procédés et compositions sont fournis utilisant de tels composés et leurs dérivés pour traiter, par exemple, les dégénérations maculaires et dystrophies ou pour atténuer les symptômes associés à de telles conditions ophtalmiques. De tels composés et leurs dérivés peuvent être utilisés en tant que thérapie à un seul agent ou en combinaison avec d'autres agents ou thérapies.

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