Methods and compositions for treating ophthalmic conditions...

A - Human Necessities – 61 – K

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A61K 31/07 (2006.01) A01N 31/04 (2006.01) A61K 35/44 (2006.01)

Patent

CA 2614627

Compounds that reduce serum retinol, serum RBP, and/or serum retinol-RBP levels may be used to treat ophthalmic conditions associated with the overproduction of waste products that accumulate during the course of the visual cycle. We describe methods and compositions using such compounds and their derivatives to treat, for example, the macular degenerations and dystrophies or to alleviate symptoms associated with such ophthalmic conditions. Such compounds and their derivatives may be used as single agent therapy or in combination with other agents or therapies.

Composés qui réduisent les taux de rétinol sérique, de protéine de liaison de rétinol (RBP) sérique et / ou de RBP / rétinol sérique et qui peuvent être utilisés pour traiter des maladies ophtalmiques associées avec la production excessive de déchets qui s'accumulent pendant le cycle visuel. La présente invention concerne des méthodes et des compositions à base de ces composés et de leurs dérivés pour traiter, par exemple, la dégénérescence maculaire et les dystrophies ou pour soulager les symptômes associés à ces maladies ophtalmiques. Ces composés et leurs dérivés peuvent être utilisés en tant qu'agent thérapeutique unique ou en combinaison avec d'autres agents ou thérapies.

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