A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/17 (2006.01) A61K 31/00 (2006.01) A61K 31/395 (2006.01) A61K 31/472 (2006.01) A61K 31/496 (2006.01) A61K 31/553 (2006.01) A61K 31/7088 (2006.01) A61K 48/00 (2006.01) A61P 25/00 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2349498
The present application is directed to the discovery that hedgehog gene products are able to protect peripheral nerve cells under conditions which otherwise result in peripheral neuropathy. Certain aspects of the invention are directed to preparations of hedgehog polypeptides, or other molecules which regulate patched or smoothened signalling, and their uses as protective agents against both acquired and hereditary neuropathies. As used herein, "peripheral neuropathy" refers to a disorder affecting a segment of the peripheral nervous system. For instance, the method of the present invention can be used as part of a treatment program in the management of neuropathies associated with systemic disease, e.g., viral infections, diabetes, inflammation; as well as genetically acquired (hereditary) neuropathies, e.g., Charcot-Marie-Tooth disease; and neuropathies caused by a toxic agent, e.g., a chemotherapeutic agent such as vincristine.
L'invention concerne la découverte de la capacité qu'ont les produits du gène hedgehog de protéger les cellules nerveuses périphériques, dans des conditions qui, dans d'autres circonstances, évolueraient en neuropathie périphérique. Certains aspects de l'invention concernent des préparations de polypeptides hedgehog ou d'autres molécules qui régulent une signalisation patched ou Smoothened ainsi que leurs utilisations en tant qu'agents de protection contre les neuropathies acquises que héréditaires. Le terme "neuropathie périphérique", tel qu'il est employé ici, se rapporte à un trouble affectant un segment du système nerveux périphérique. Par exemple, la méthode selon l'invention peut être utilisée en tant que partie d'un programme de traitement des neuropathies associées à une maladie systémique, par exemple, des infections virales, le diabète, les inflammations, les neuropathies acquises par les gènes (héréditaires), par exemple, la maladie de Charcot-Marie, ainsi que les neuropathies dues à un agent toxique, par exemple, un agent chimiothérapeutique tel que la vincristine.
Galdes Alphonse
Mahanthappa Nagesh
Biogen Inc.
Borden Ladner Gervais Llp
Curis Inc.
Ontogeny Inc.
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