Methods and compositions for treating periodontal disease

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/506 (2006.01) A61K 31/34 (2006.01) A61K 31/365 (2006.01) A61K 31/415 (2006.01) A61K 31/42 (2006.01) A61K 31/444 (2006.01) A61K 31/4709 (2006.01) A61K 45/06 (2006.01) A61P 1/02 (2006.01)

Patent

CA 2432504

The present invention provides for a method for the treatment of alveolar bone loss due to periodontal disease in a subject in need of such treatment comprising administration of a therapeutically effective amount of an .alpha.v.beta.3 integrin receptor antagonist in combination with a therapeutically effective amount of a COX-2 inhibitor. Further, the present invention provides for pharmaceutical compositions useful in the methods of the present invention, as well as a method of manufacture of a medicament useful for treating the alveolar bone loss due to periodontal disease.

La présente invention concerne une méthode de traitement d'une perte osseuse alvéolaire provoquée par une parodontopathie consistant à administrer une quantité efficace thérapeutiquement d'un antagoniste de récepteur d'intégrine .alpha.v.beta.3 mélangée à une quantité efficace thérapeutiquement d'un inhibiteur COX-2, chez un sujet nécessitant un tel traitement. En outre, cette invention a trait à des compositions pharmaceutiques utilisées dans les méthodes susmentionnées, ainsi qu'à un procédé d'élaboration d'un médicament destiné au traitement de la perte osseuse alvéolaire provoquée par une parodontopathie.

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