Methods and compositions for treating primary and secondary...

Details Methods and compositions for treating primary and secondary... Methods and compositions for treating primary and secondary...

A - Human Necessities

61

K

A61K 38/19 (2006.01) A61K 31/00 (2006.01) A61K 31/513 (2006.01) A61K 31/54 (2006.01) A61K 31/549 (2006.01) A61K 38/20 (2006.01) A61K 38/21 (2006.01) A61K 45/06 (2006.01) A61P 25/00 (2006.01) A61P 31/00 (2006.01)

Patent

CA 2310534

Methods and compositions for the treatment and/or prophylaxis and/or suppression of primary and/or secondary tumors of the central nervous system (brain and spinal cord, eyes) in mammalian subjects are disclosed, wherein an effective dose of a methylol transfer agent such as Taurolidine and/or Taurultam and/or a bioequivalent is administered to a mammalian subject suffering from, or at risk of growth of, tumors of the central nervous system. Furthermore, methods for local application of Taurolidine and/or Taurultam and/or a bioequivalent in solution are disclosed using microdialysis methods, irrigation methods, implantion methods and angiographic methods.

Des méthodes et des compositions destinées au traitement et/ou à la prophylaxie et/ou à la suppression de tumeurs primaires et/ou secondaires du système nerveux central (cerveau et moelle épinière, yeux) chez des sujets mammaliens sont divulguées. Dans ces méthodes, une dose efficace d'un agent de transfert du groupe méthylol comme la taurolidine et/ou le taurultam et/ou un bioéquivalent est administré à un sujet mammalien présentant, ou à risque de présenter, des tumeurs du système nerveux central. En outre, des méthodes destinées à l'application locale de taurolidine et/ou de taurultam et/ou d'un bioéquivalent en solution sont divulguées, lesquelles font appel à des méthodes de microdialyse, à des méthodes d'irrigation, à des méthodes d'implantation et à des méthodes angiographiques.

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