C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/72 (2006.01) A61K 38/18 (2006.01) A61P 5/28 (2006.01) A61P 13/08 (2006.01) A61P 35/00 (2006.01) C07K 14/47 (2006.01) C07K 19/00 (2006.01)
Patent
CA 2681917
A polypeptide comprising an androgen binding region, the androgen binding region capable of binding to an androgen at a sufficient affinity or avidity such that upon administration of the polypeptide to a mammalian subject the level of biologically available androgen is decreased. Specifically disclosed is an AR IgGl Fc fusion protein, comprising the androgen binding domain of human androgen receptor and the Fc region of IgG. This fusion protein is used in the treatment of prostate cancer and testosterone flare.
L'invention concerne un polypeptide qui comprend une région de liaison d'androgène, ladite région pouvant se lier à un androgène avec une affinité ou avidité suffisante pour réduire le niveau d'androgène biologiquement disponible chez un sujet mammifère lorsque ce polypeptide est administré audit sujet. L'invention concerne spécifiquement une protéine hybride AR IgGl Fc qui comprend le domaine de liaison d'androgène du récepteur androgène humain et la région Fc de l'IgG. Cette protéine hybride est utilisée dans le traitement du cancer de la prostate cancer et de l'élévation passagère de la testostéronémie.
Corcoran Niall
Costello Anthony
Hovens Christopher
Corcoran Niall
Costello Anthony
Hovens Christopher
Sim & Mcburney
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