Methods and compositions for treating rheumatoid arthritis

Details Methods and compositions for treating rheumatoid arthritis Methods and compositions for treating rheumatoid arthritis

A - Human Necessities

61

K

A61K 31/415 (2006.01) A61K 31/16 (2006.01) A61K 31/18 (2006.01) A61K 31/425 (2006.01)

Patent

CA 2529873

This application relates to methods and compositions for treating rheumatoid arthritis by administering a combination therapy comprising methotrexate and an antibody to alpha 4 integrin or an immunologically active antigen binding fragment in therapeutically effective amounts. The application also relates generally to methods and compositions for treating rheumatoid arthritis by administering a combination therapy comprising methotrexate and small molecule alpha-4 integrin antagonist that inhibits the alpha-4 integrin ( 4 integrin) interaction with VCAM-1. The invention further relates to methods of preparing the compounds and methods of using the compounds and compositions.

L'invention concerne des méthodes et des compositions de traitement de la polyarthrite rhumatoïde reposant sur l'administration d'une polythérapie contenant du méthotrexate et un anticorps à une intégrine alpha 4 ou un fragment de liaison d'antigène actif sur le plan immunologique dans des quantités efficaces en thérapie. Cette invention a également trait à des méthodes et à des compositions de traitement de la polyarthrite rhumatoïde par administration d'une polythérapie contenant du méthotrexate et un antagoniste de l'intégrine alpha-4 de petite molécule qui permet d'inhiber l'interaction de l'intégrine alpha-4 (intégrine .alpha.-4) avec VCAM-1. Ladite invention a aussi pour objet des méthodes de préparation et d'utilisation des composés et des compositions.

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