Methods and compositions for treating rheumatoid arthritis

Details Methods and compositions for treating rheumatoid arthritis Methods and compositions for treating rheumatoid arthritis

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2528723

This application relates to methods and compositions for treating rheumatoid arthritis by administering a combination therapy comprising methotrexate and an antibody to alpha 4 integrin or an immunologically active antigen binding fragment in therapeutically effective amounts. The application also relates generally to methods and compositions for treating rheumatoid arthritis by administering a combination therapy comprising methotrexate and small molecule alpha-4 integrin antagonist that inhibits the alpha-4 integrin ( 4 integrin) interaction with VCAM-1. The invention further relates to methods of preparing the compounds and methods of using the compounds and compositions.

La présente invention concerne des méthodes et des compositions de traitement de la polyarthrite rhumatoïde par administration d'un traitement combiné comprenant du méthotrexate et un anticorps de l'intégrine alpha 4 ou un fragment de fixation à l'antigène immunologiquement actif en quantités thérapeutiquement efficaces. L'invention concerne également, de manière générale, des méthodes et des compositions de traitement de la polyarthrite rhumatoïde par administration d'un traitement combiné comprenant du méthotrexate et une petite molécule antagoniste de l'intégrine alpha 4 qui inhibe l'interaction de l'intégrine alpha 4 (intégrine .alpha.4) avec une VCAM-1. L'invention concerne en outre des méthodes de préparation desdits composés et des méthodes d'utilisation desdits composés et desdites compositions.

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