Methods and compositions for treating t cell mediated...

A - Human Necessities – 61 – K

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A61K 31/573 (2006.01) A61K 31/00 (2006.01) A61K 31/12 (2006.01) A61K 31/18 (2006.01) A61K 31/19 (2006.01) A61K 31/192 (2006.01) A61K 31/196 (2006.01) A61K 31/341 (2006.01) A61K 31/365 (2006.01) A61K 31/40 (2006.01) A61K 31/405 (2006.01) A61K 31/407 (2006.01) A61K 31/415 (2006.01) A61K 31/4152 (2006.01) A61K 31/42 (2006.01) A61K 31/421 (2006.01) A61K 31/444 (2006.01) A61K 31/50 (2006.01) A61K 31/5415 (2006.01) A61K 31/5575 (2006.01) A61K 31/58 (2006.01) A61K 31/60 (2006.01) A61K 31/616 (2006.01) A61K 31/63 (

Patent

CA 2484989

The present invention provides a method for preventing or treating a T cell mediated inflammatory/autoimmune disease or disorder in a subject having a glucocorticoid regulation deficiency, where the method comprises administering to a subject in need of such treatment a cyclooxygenase-2 inhibitor. The Cox-2 inhibitor may be administered in combination with a glucocorticoid. The Cox-2 inhibitor can be a Cox-2 selective inhibitor. Compositions, pharmaceutical compositions and kits are provided for carrying out the method.

L'invention concerne une méthode de prévention ou de traitement d'une maladie ou d'un trouble inflammatoire/autoimmun induit par les lymphocytes T chez un sujet souffrant d'une déficience dans la régulation des glucocorticoïdes. Cette méthode consiste à administrer à un sujet ayant besoin d'un tel traitement un inhibiteur de la cyclooxygénase-2. L'inhibiteur de la Cox-2 peut être administré en combinaison avec un glucocorticoïde. L'inhibiteur de la Cox-2 peut être un inhibiteur sélectif de la Cox-2. Par ailleurs, l'invention concerne des compositions, des compositions pharmaceutiques ainsi que des kits permettent d'appliquer cette méthode.

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