A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 45/06 (2006.01) A61K 31/203 (2006.01)
Patent
CA 2484829
Tinea versicolor is a fungal infection of the skin an often results in a discoloration or dyspigmentation of the infected skin. The present invention provides as a combination therapy an antifungal for treating the fungal infection and a retinoid for correcting the skin pigmentation. Preferred antifungal agents are those which are also CYP-26 inhibitors, which delay the natural enzymatic breakdown of retinoids in the skin. Alternatively, a non-CYP- 26 inhibiting antifungal can be used in combination with a retinoid, with a CYP-26 inhibitor (antifungal or not) optionally added.
La Pityriasis versicolor est une infection fongique de la peau qui entraîne souvent la décoloration ou la dépigmentation de la peau infectée. L'invention fournit en tant que thérapie combinée un antifongique permettant de traiter l'infection fongique et un rétinoïde afin de corriger la pigmentation de la peau. Des agents antifongiques préférés sont ceux qui sont également des inhibiteurs CYP-26 qui retardent la rupture enzymatique naturelle des rétinoïdes dans la peau. Dans une alternative, un antifongique inhibiteur non CYP-26 peut être utilisé en combinaison avec un rétinoïde, avec un inhibiteur CYP-26 (antifongique ou non) facultativement ajouté.
Birnbaum Jay E.
Birnbaum Jay E.
Smart & Biggar
The Regents Of The University Of Michigan
LandOfFree
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