A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 16/28 (2006.01)
Patent
CA 2555365
Compositions, methods, and combination therapies for the treatment of lymphomas, leukemias, melanomas, prostate cancer, and metastatic disease are provided. Specifically, compositions comprising anti-.alpha.4 integrin immunoglobulins or immunoglobulins that bind to an .alpha.4 integrin ligand (e.g., MadCAM-1 and VCAM-1) are disclosed for use in inhibiting tumor growth and progression and inhibition of metastases. A preferred immunoglobulin for use in treating tumors and metastases is natalizumab. The compositions and methods using these immunoglobulins can be used alone or in combination with other reagents and cancer treatment modalities.
L'invention concerne des compositions, des méthodes et des polythérapies destinées au traitement de lymphomes, de leucémies, de mélanomes, du cancer de la prostate et de maladie métastatique. Notamment, cette invention a pour objet des compositions contenant des immunoglobines d'intégrine anti-.alpha.4 ou des immunoglobulines qui se lient à un ligand d'intégrine .alpha.4 (par exemple, MadCAM-1 et VCAM-1), lesdites compositions étant destinées à l'inhibition de croissance tumorale et à la progression et à l'inhibition de métastases. Le natalizumab constitue une immunoglobuline préférée à utiliser dans le traitement de tumeurs et de métastases. Les compositions et les méthodes utilisant ces immunoglobulines peuvent être utilisées seules ou en combinaison avec d'autres réactifs et modalités de traitement de cancer.
Barrigar Intellectual Property Law
Elan Pharmaceuticals Inc.
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