A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/215 (2006.01) A61K 9/70 (2006.01) A61K 31/216 (2006.01) A61P 13/00 (2006.01)
Patent
CA 2257121
A method for treating urinary incontinence while avoiding concomitant liability of adverse effects associated with racemic oxybutynin is disclosed. The method comprises administering from 100 mg to 1 000 mg/day of (S)-oxybutynin, (S)-desethyloxybutynin or a pharmaceutically acceptable salt thereof, substantially free of the corresponding R enantiomer. Pharmaceutical compositions in the form of tablets soft elastic gelatin capsules and transdermal devices comprising an acceptable corner and up to 500 mg of (S)-oxybutynin or (S)-desethyloxybutynin are also disclosed.
Le procédé de l'invention permet de traiter l'incontinence urinaire tout en évitant le risque concomitant lié aux effets nocifs associés à l'oxybutynine racémique. Le procédé consiste à administrer entre 100 mg et 1 000mg par jour de (S)-oxybutynine ou de (S)-déséthyloxybutynine, ou un sel pharmaceutiquement acceptable desdits composés, sensiblement dépourvus de leur énantiomère R respectif. L'invention concerne aussi des compositions pharmaceutiques préparées sous forme de comprimés, de capsules de gélatine molles élastiques, ainsi qu'une trousse transdermique comprenant un transporteur acceptable et au maximum 500 mg de (S)-oxybutynine ou de (S)-déséthyloxybutynine.
Aberg Gunnar
Mccullough John R.
Borden Ladner Gervais Llp
Sepracor Inc.
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