Methods and compositions for treatment of angiogenic diseases

Details Methods and compositions for treatment of angiogenic diseases Methods and compositions for treatment of angiogenic diseases

C - Chemistry, Metallurgy

07

K

530/7.1, 167/103

C07K 14/515 (2006.01) A61K 38/17 (2006.01) A61K 38/19 (2006.01) C07K 14/435 (2006.01) C07K 14/52 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2007026

Abstract of the Disclosure The subject invention pertains to the use of recombinant PF4 (rPF4) as well as full length novel analogs (mutants) of rPF4, and peptide fragments thereof, to inhibit angiogenesis. rPF4, analogs, and certain fragments are shown to have utility for treating angiogenic diseases and for the inhibition of endothelial cell proliferation.

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