Methods and compositions for treatment of autoimmune diseases

Details Methods and compositions for treatment of autoimmune diseases Methods and compositions for treatment of autoimmune diseases

C - Chemistry, Metallurgy

08

G

C08G 69/10 (2006.01) A61K 38/02 (2006.01) C08L 77/00 (2006.01)

Patent

CA 2558655

The present invention provides methods and compositions for treating autoimmune diseases and other unwanted immune reactions comprising administering a copolymer that binds to one or more HLA-DQ molecules and modulates DQ-restricted T cell responses. The copolymers are random copolymers of amino acids and copolymers comprising anchor residues to facilitate binding to the DQ binding pockets.

L'invention concerne des méthodes et des compositions pour traiter des maladies auto-immunes et d'autres réactions immunitaires non voulues. Ces méthodes consistent à administrer un copolymère se liant à au moins une molécule HLA-DQ et modulant les réactions de cellule T restreintes par DQ. Les copolymères sont des copolymères aléatoires d'acides aminés et des copolymères comprenant des résidus d'ancrage pour faciliter la liaison aux poches de liaison DQ.

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