Methods and compositions for treatment of bone defects with...

A - Human Necessities – 61 – K

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A61K 35/50 (2006.01) C12N 5/071 (2010.01) A61P 35/00 (2006.01)

Patent

CA 2734446

Provided herein are osteogenic placental adherent cells (OPACs), methods of using OPACs and OPAC populations, and methods of culturing, proliferating, expanding, or differentiating the OPACs. Further provided herein are methods of using the OPACs to formulate implantable or injectable compositions suitable for administration to a subject. Still further provided herein are provides methods for treating bone defects with OPACs and compositions comprising OPACs. Also provided herein are methods of using OPACs in the treatment and management of multiple myeloma, e.g., reducing the progression of, halting the progression of, or improving, one or more symptoms of multiple myeloma in an individual having multiple myeloma, comprising administering a plurality of OPACs to the individual.

La présente invention concerne des cellules placentaires ostéogéniques adhérentes (OPAC), des méthodes dutilisation des OPAC et des populations dOPAC, et des procédés de culture, de prolifération, dexpansion, ou de différenciation des OPAC. La présente invention concerne également des méthodes dutilisation des OPAC pour préparer des compositions implantables ou injectables, adaptées à ladministration à un sujet. La présente invention concerne en outre des méthodes pour le traitement de déficits osseux au moyen dOPAC et des compositions comprenant des OPAC. La présente invention concerne également des méthodes dutilisation des OPAC dans le traitement et la prise en charge du myélome multiple, par exemple, pour réduire ou stopper la progression dun ou de plusieurs symptômes du myélome multiple, ou atténuer ceux-ci, chez un individu atteint de myélome multiple, comprenant ladministration à lindividu dune pluralité dOPAC.

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