A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/506 (2006.01) A61K 9/10 (2006.01) A61K 47/36 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2356087
The present invention relates to methods and compositions comprising at least one endothelin antagonist, preferably in combination with a poly-.beta.-1.fwdarw.-4-N-acetylglucosamine (p-G1cNAc) polysaccharide matrix, for use in the treatment of cancer and other proliferative diseases. The endothelin antagonist can be a peptide or non-peptide compound, and the p-G1cNAc matrix of the invention is comprised of a polymer of high molecular weight whose constituent monosaccharide sugars are attached in a .beta.-1.fwdarw.-4 conformation, and which is free of proteins, and substantially free of single amino acids, and other organic and inorganic contaminants. The compositions and methods of the invention are useful for inhibiting the growth of tumors and other neoplastic cells and/or for inhibiting the metastasis of neoplastic cells in vivo.
L'invention concerne des techniques et des compositions comprenant au moins un antagoniste de l'endothéline, de préférence en combinaison avec une matrice polysaccharidique de poly- beta -1}-4-N-acétylglucosamine (p-G1cNAc), utilisée pour traiter le cancer ou d'autres maladies prolifératives. L'antagoniste de l'endothéline peut être un composé peptidique ou non peptidique, et la matrice p-G1cNAc est constituée d'un polymère de poids moléculaire élevé dont les sucres monosaccharides constituants sont fixés en une conformation beta -1}-4, est exempte de protéines, et sensiblement exempte d'acides aminés seuls et d'autres contaminants organiques et non organiques. Les compositions et les techniques de cette invention sont utiles pour inhiber la croissance des tumeurs et d'autres cellules néoplasiques et/ou pour inhiber in vivo les métastases desdites cellules néoplasiques.
Finkielsztein Sergio
Pariser Ernest R.
Vournakis John N.
Marine Polymers Technologies Inc.
Osler Hoskin & Harcourt Llp
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