Methods and compositions for treatment of hematologic cancers

Details Methods and compositions for treatment of hematologic cancers Methods and compositions for treatment of hematologic cancers

A - Human Necessities

61

K

A61K 39/125 (2006.01) A61P 35/00 (2006.01) A61P 35/02 (2006.01)

Patent

CA 2577692

The present invention relates to oncolytic Picornaviruses and methods and compositions for treating subjects having hematologic cancers. These include methods and compositions for treatment of myeloma, using disclosed Picornavirus such as Coxsackievirus, in methods of direct or indirect administration to subjects and ex vivo purging of malignant cells within auto grafts prior to transplantation.

La présente invention concerne des Picornavirus oncolytiques et des procédés et compositions destinés au traitement de sujets atteints de cancers hématologiques. Ceux-ci comprennent des procédés et des compositions destinés au traitement de myélomes, en utilisant le Picornavirus décrit, tel que le Coxsackievirus, dans des procédés d~administration directe ou indirecte à des sujets et d~élimination ex vivo de cellules malignes présentes dans des autogreffes avant la transplantation.

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