A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61P 19/02 (2006.01) A61P 37/00 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C07K 19/00 (2006.01) G01N 33/53 (2006.01) G01N 33/543 (2006.01) G01N 33/566 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2384115
A method for treating inflammatory joint diseases by inhibiting cadherin-11 mediated cellular function using a cadherin-11 modulating agent is provided. Also provided are screening assays for identifying pharmaceutical lead compounds capable of modulating cellular functions of cadherin-11 such as cell proliferation, apoptosis, factor secretion, and binding of cadherin-11 to cadherin-11 counter-receptor inhibiting binding of cadherin-11 to its counter- receptor either in the context of a cell or in soluble form.
La présente invention concerne une technique par laquelle on traite des maladies articulaires inflammatoires en inhibant la fonction cellulaire induite par la cadhérine-11 par l'utilisation d'un agent de modulation de la cadhérine-11. Cette invention concerne aussi des recherches destinées à identifier des composés de plomb pharmaceutiques capables de moduler les fonctions cellulaires de la cadhérine-11, telles que la prolifération des cellules, l'apoptose, la sécrétion de facteur, et la liaison de cadhérine-11 au contre-récepteur de cadhérine-11 inhibant la liaison de la cadhérine-11 à ce contre-récepteur de cadhérine-11 tant dans le contexte d'une cellule que dans une forme soluble.
Brenner Michael B.
Valencia Xavier
Brigham And Women's Hospital Inc.
Smart & Biggar
LandOfFree
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