Methods and compositions for treatment of neovascularization

Details Methods and compositions for treatment of neovascularization Methods and compositions for treatment of neovascularization

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61P 27/02 (2006.01) C12N 9/06 (2006.01)

Patent

CA 2751438

Disclosed herein are methods and compositions for treatment of neovascularization, in particular, ocular neovascularization and resultant fibrotic damage. Compositions comprise inhibitors of the ac-tivity of one or more lysyl oxidase-type enzymes, and the methods include methods for making the inhibitors and methods for administration of the inhibitors to a subject in need thereof.

La présente invention concerne des méthodes et des compositions destinées au traitement de la néovascularisation, en particulier de la néovascularisation oculaire et de lésions fibrogènes en résultant. L'invention porte en outre sur des compositions comprenant des inhibiteurs de l'activité d'une ou de plusieurs enzymes de type lysyle oxydase. Lesdites méthodes comprennent des méthodes de réalisation desdits inhibiteurs et des méthodes d'administration de ces inhibiteurs à un sujet en ayant besoin.

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