Methods and compositions for treatment or prevention of...

A - Human Necessities – 61 – K

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A61K 31/366 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2697043

The present invention comprises methods and compositions for the treatment or prevention of radiation-induced fibrosis. Methods and compositions for the inhibition of CTGF are disclosed herein. Methods and compositions for treatment of neoplastic disease are disclosed herein. Inhibition of CTGF in humans or animals that have been exposed to ionizing radiation results in treatment or prevention of radiation-induced fibrosis.

La présente invention concerne des procédés et des compositions pour le traitement ou la prévention d'une fibrose induite par rayonnement. Des procédés et des compositions pour l'inhibition du CTGF (facteur de croissance de tissu conjonctif) sont présentés ici. Des procédés et des compositions pour le traitement de la maladie néoplasique sont présentés ici. L'inhibition du CTGF chez les êtres humains ou les animaux qui ont été exposés aux résultats d'un rayonnement ionisant entraîne le traitement ou la prévention d'une fibrose induite par rayonnement.

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