Methods and compositions for use in perfusion applications

Details Methods and compositions for use in perfusion applications Methods and compositions for use in perfusion applications

A - Human Necessities

61

M

A61M 1/00 (2006.01) A01N 1/02 (2006.01) A61K 35/14 (2006.01)

Patent

CA 2362051

Methods and compositions for use in perfusion applications are provided. In the subject methods, a subject or derivative thereof, e.g. isolated organ or tissue, is infused, perfused and/or transfused with at least two fluid compositions. The first fluid composition is a non-naturally occurring biological buffer free plasma-like solution and the second fluid composition is a fluid blood composition. In a preferred embodiment, an additional volume of the first solution, or a derivative thereof, is administered to the patient following introduction of the fluid blood composition. Also provided are kits and systems for performing the subject methods. The subject methods and compositions find use in variety of perfusion applications, including the treatment of hypothermic surgical applications, cryogenic procedures, and the like.

L'invention porte sur des procédés et des compositions destinés à être utilisés dans des applications de perfusion. Selon ces procédés, un sujet ou un dérivé de celui-ci tel qu'un organe ou tissu isolé est injecté, perfusé et/ou transfusé avec au moins deux compositions de fluide. La première composition de fluide est une solution de type plasma exempte de tampon biologique d'origine non naturelle, et la seconde composition de fluide est une composition de fluide sanguin. Selon une réalisation préférée, un volume supplémentaire de la première solution ou un dérivé de celle-ci est administré au patient après l'introduction de la composition de fluide sanguin. L'invention porte également sur des kits et des systèmes permettant de réaliser ces procédés. Les procédés et compositions de cette invention s'avèrent utiles dans l'utilisation d'une variété d'applications de perfusion telles que le traitement d'applications chirurgicales hypothermiques, des techniques cryogéniques et autres.

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