C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/861 (2006.01) A61K 39/012 (2006.01) A61K 39/235 (2006.01) A61P 33/02 (2006.01) C12N 7/01 (2006.01)
Patent
CA 2746310
The present invention relates to a coccidiosis vaccine to protect poultry against Eimeria infection, comprising a recombinant avian adenovirus vector comprising in frame a (heterologous) promoter linked to a hydrophobic signal sequence for membrane anchoring, or linked to an hydrophobic secretion signal and a cleavage site to allow secretion; a multiple cloning site for in frame insertion of an Eimeria antigen ORF such as derived from the r56, 82 kDa, and/or TFP250 antigens; a polyadenylation signal; and an avian adenovirus genome.
La présente invention concerne un vaccin contre la coccidiose pour protéger les volailles contre une infection par Eimeria, comprenant un vecteur d'adénovirus aviaire recombinant comprenant en phase un promoteur (hétérologue) lié à une séquence signal hydrophobe pour l'ancrage membranaire, ou lié à un signal de sécrétion hydrophobe et un site de clivage pour permettre la sécrétion; un site de clonage multiple pour l'insertion dans le cadre d'un ORF d'antigène d'Eimeria tel que celui dérivé des antigènes r56, 82 kDa, et/ou TFP250; un signal de polyadénylation; et un génome d'adénovirus aviaire.
Goudreau Gage Dubuc
Vectogen Pty Ltd
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