A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/12 (2006.01) A61K 31/4174 (2006.01) A61K 31/4196 (2006.01) A61K 31/496 (2006.01) A61K 31/506 (2006.01) A61P 31/00 (2006.01) A61P 31/04 (2006.01) A61P 31/10 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2727939
Provided are novel compositions and therapeutic methods for treating bacterial and fungal disease with cyclic ana-logues of histatin. The cyclic analogues of histatin are advantageously more potent but less toxic than currently used anti-microbial agents. In addition, compositions comprising the cyclic analogue with other anti-microbial agents such as azole compounds are disclosed.
La présente invention concerne de nouvelles compositions et des méthodes thérapeutiques de traitement des maladies bactériennes et fongiques avec des analogues cycliques de l'histatine. Les analogues cycliques de l'histatine sont avantageusement plus puissants mais moins toxiques que les agents antimicrobiens utilisés actuellement. Cette invention porte également sur des compositions comprenant l'analogue cyclique ainsi que d'autres agents antimicrobiens tels que des composés azole.
Brewer Dyanne Patricia
Lajoie Gilles Andre
Vilk Greg John Adams
Gowling Lafleur Henderson Llp
The University Of Western Ontario
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