Methods and compositions for using alveolar macrophage...

Details Methods and compositions for using alveolar macrophage... Methods and compositions for using alveolar macrophage...

C - Chemistry, Metallurgy

12

Q

C12Q 1/34 (2006.01) C12N 9/20 (2006.01)

Patent

CA 2606228

The present invention is directed to methods and compositions for improving pulmonary surfactant catabolism. More specifically, the specification describes methods and compositions for making and using a lysosomal phospholipase A2 in methods for the diagnosis, and treatment of disorders of phospholipid catabolism such as pulmonary alveolar proteinosis.

La présente invention concerne des procédés et des compositions permettant l'amélioration du catabolisme des tensioactifs pulmonaires. De manière plus spécifique, la présente invention concerne des procédés et des compositions permettant la fabrication et l'utilisation d'une phospholipase A2 lysosomiale dans des procédés permettant de diagnostiquer et de traiter les troubles de catabolisme des phospholipides tels que la protéinose alvéolaire pulmonaire.

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