Methods and compositions for vaccination of animals with...

C - Chemistry – Metallurgy – 07 – K

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C07K 14/08 (2006.01) A61K 39/12 (2006.01) A61K 48/00 (2006.01) C12N 15/40 (2006.01) C12N 15/85 (2006.01) C12N 15/863 (2006.01)

Patent

CA 2620667

Pigs challenged with hypoglycosylated variants of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) major surface protein GP5 exhibited increased production of PRRSV-neutralizing antibodies relative to the levels of neurtalizing antibodies produced by pigs immunized with wild type (wt) or glycosylated GP5. This invention provides for methods of obtaining improved immune responses in pigs to PRRSV, compositions useful for obtaining the improved immune responses as well as isolated polynucleotides that encode hypoglycosylated variants of PRRSV major surface protein GP5.

Des porcs chez qui on a introduit des variants hypoglycosylés de la principale protéine de surface GP5 du virus du syndrome dysgénésique et respiratoire du porc (PRRSV) ont révélé une production plus importante d'anticorps neutralisant le PRRSV par rapport aux niveaux d'anticorps neutralisants produits par des porcs immunisés avec une protéine GP5 glycosylée ou de type sauvage. Cette invention concerne des méthodes permettant d'obtenir des meilleures réponses immunitaires au PRRSV chez des porcs. Cette invention concerne également des compositions utiles pour obtenir les réponses immunitaires améliorées, ainsi que des polynucléotides isolés codant pour des variants hypoglycosylés de la principale protéine de surface GP5 du PRRSV.

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