C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 251/18 (2006.01) A61K 31/53 (2006.01) A61P 17/06 (2006.01) A61P 19/02 (2006.01) A61P 35/00 (2006.01) C07D 251/44 (2006.01) C07D 251/50 (2006.01) C07D 251/52 (2006.01) C07D 251/66 (2006.01) C07D 251/70 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 407/04 (2006.01) C07D 409/04 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 413/10 (2006.01) C07D 413/1
Patent
CA 2499964
The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.
L'invention concerne des procédés et des compositions comprenant des composés destinés à traiter des états pathophysiologiques générés par des réponses inflammatoires. L'invention concerne, en particulier, des composés inhibant ou bloquant l'induction produite par des protéines glyquées de réponse inflammatoire associée à la signalisation dans les cellules endothéliales. L'invention concerne également des composés inhibant la prolifération du muscle lisse. L'invention concerne, en particulier, des composés inhibant la prolifération cellulaire du muscle lisse par modulation des HSPG, tels que le perlecan. L'invention concerne enfin l'utilisation de ces composés pour traiter des vasculopathies occlusives caractérisées par une prolifération du muscle lisse tels que la resténose et l'athérosclérose.
Alexander Christopher W.
Alluri Sesha Sridevi
Kumar Potlapally Rajender
Pal Manojit
Pillarisetti Sivaram
Marks & Clerk
Reddy Us Therapeutics Inc.
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