Methods and compositions related to a matrix chip

Details Methods and compositions related to a matrix chip Methods and compositions related to a matrix chip

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C12M 1/34 (2006.01) C12Q 1/02 (2006.01) C12Q 1/44 (2006.01) C40B 30/00 (2006.01)

Patent

CA 2542443

Embodiments of the invention relate to devices and methods for evaluating the interactions between cells and between cells and matrix materials wherein the cellular distribution pattems formed as a result of such interactions are indicators of the invasive potential(s) of the cells. Furthermore, such devices and methods can provide indications of the preferred sites of metastasis of invasive cells; the efficacy of an anti-cancer drug applied to such cells; and the potential for agents to promote or enhance tumor growth or metastasis.

Certains modes de réalisation de l'invention concernent des dispositifs et des méthodes permettant d'évaluer les interactions entre des cellules et entre des cellules et des matières matricielles, les modèles de répartition cellulaire résultant de ces interactions étant des indicateurs du ou des potentiels invasifs des cellules. En outre, ces dispositifs et ces méthodes permettent d'obtenir des indications sur les sites préférés de métastase de cellules invasives, l'efficacité d'un médicament anticancéreux appliqué sur ces cellules, et la capacité d'agents à favoriser ou stimuler la croissance tumorale ou la métastase.

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