C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/864 (2006.01) A61B 5/055 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07H 21/00 (2006.01) C12N 7/01 (2006.01) C12N 15/00 (2006.01) C12N 15/11 (2006.01) A61K 49/00 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2649182
Embodiments of the invention are generally directed to compositions and methods of delivering one or more transgene to a target cell, such as a tumor cell, in a site-specific manner to achieve enhanced expression and to constructs and compositions useful in such applications. In certain aspects, expression from a therapeutic nucleic acid may be assessed prior to administration of a treatment or diagnostic procedure to or on a subject.
Les modes de réalisation de la présente invention concernent généralement des compositions et des procédés permettant d'administrer un ou plusieurs transgènes dans une cellule cible, telle une cellule tumorale, de façon spécifique au site afin de parvenir à une expression accrue et de créer des compositions se révélant utiles dans de telles applications. Dans certains aspects, l'expression d'un acide nucléique thérapeutique peut être évaluée avant l'administration d'un traitement ou la procédure de diagnostic relative à un sujet.
Alauddin Mian
Arap Wadih
Gelovani Juri
Hajitou Amin
Marini Frank C. III
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
The Board Of Regents Of The University Of Texas System
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