Methods and compositions related to internalizing rgd peptides

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 7/08 (2006.01) A61K 38/04 (2006.01) A61K 47/48 (2006.01) A61K 49/14 (2006.01) A61K 51/08 (2006.01) A61P 35/00 (2006.01) C07K 7/00 (2006.01) C07K 7/06 (2006.01) C07K 14/705 (2006.01) C07K 14/78 (2006.01)

Patent

CA 2710554

Disclosed are compositions and methods useful for targeting tissue undergoing angiogenesis or to cells or tissue expressing .alpha.v integrins. The compositions and methods are based on peptide sequences that selectively bind to and home to tissue undergoing angiogenesis or to cells or tissue expressing .alpha.v integrins in animals. The disclosed targeting is useful for delivering therapeutic and detectable agents to tissue experiencing angiogenesis or to cells or tissue expressing .alpha.v integrins.

La présente invention concerne des compositions et des procédés utiles pour cibler des tissus où se produit une angiogenèse ou des cellules ou tissus exprimant les intégrines av. Les compositions et procédés sont basés sur des séquences peptidiques qui se lient sélectivement à des tissus où se produit une angiogenèse et se dirigent vers ceux-ci ou à des cellules ou tissus exprimant les intégrines av chez les animaux. Le ciblage décrit est utile pour administrer des agents thérapeutiques et détectables à des tissus où se produit l'angiogenèse ou à des cellules ou tissus exprimant les intégrines av.

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